منابع مشابه
Cardiac Protection with Targeted Drug Delivery to Ischemic-Reperfused Myocardium
The concept of targeted drug delivery implies selective accumulation of the drug in the tissue affected by the pathological process after systemic administration of the drug and its carrier with minimal effect of the former on the intact organs and tissues (Lammers et al., 2010). The idea of targeted delivery has been first suggested by Paul Erhlich in 1906 when he introduced the concept of «ma...
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Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel...
متن کاملProtection of the ischemic myocardium during the reperfusion: between hope and reality.
The heart is an organ that requires an important energy input to ensure its contractile function. Myocardial ischemia happens when there is a deficiency of blood flow that is responsible for the passage from an aerobic to anaerobic metabolism. Myocardial ischemia results from an imbalance between inputs and the needs of nutrient and oxygen to the myocardium. The restoration of myocardial perfus...
متن کاملEndocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue
Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mo...
متن کاملProtection of the myocardium during ischemia and reperfusion : Na(+)/H(+) exchange inhibition versus ischemic preconditioning.
The hypothesis that sarcolemmal Na /H exchanger activity may contribute to myocardial injury during ischemia and reperfusion was first published in 1985,1 preceding by 1 year the first description of the ischemic preconditioning phenomenon.2 Initial pharmacological evidence in support of the Na/H exchanger hypothesis was subsequently provided by Karmazyn,3 who showed that amiloride (an inhibito...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1978
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)41020-9